[Paper Published] Research on MMP-7-Mediated Liver Fibrosis in MASH Mouse Models Published in The FASEB Journal

Medical Education Co., Ltd. (Headquarters: Suginami-ku, Tokyo; CEO: Takashi Ochiai) is pleased to announce that the research paper 'CBP/β-Catenin Signaling in Hepatocytes Plays Pivotal Roles in MMP-7-Mediated Liver Fibrosis in a Metabolic Dysfunction-Associated Steatohepatitis Mouse Model' by Dr. Kiminori Kimura and colleagues at the Department of Hepatology, Tokyo Metropolitan Komagome Hospital, has been published in the academic journal 'The FASEB Journal.' This paper examines the involvement of CBP/β-catenin signaling and MMP-7 in hepatocytes within a MASH mouse model using CDAHFD, analyzing changes in fibrosis when MMP-7 is inhibited or deleted. MEDICAL FIG., operated by Medical Education Co., Ltd., was responsible for producing the figures included in this paper. The figure used in this study was designed to organize and illustrate the progression from MMP-7 induction via the β-catenin/CBP/p300 pathway in hepatocytes to hepatic stellate cell activation and subsequent fibrosis formation in the MASH mouse model.