[TTY Biopharm] Announcement regarding the COO change at subsidiary 'China Chemical & Pharmaceutical Co., Ltd.'

1. Type of Personnel Change (Spokesperson, Acting Spokesperson, Key Operating Executive (CEO, COO, CMO, CSO, etc.), CFO, Chief Accounting Officer, Corporate Governance Officer, CISO, Head of R&D, Internal Audit Head, or Litigation/Non-litigation Agent): COO 2. Date of Occurrence: 115/06/05 3. Name, Title, and Resume of the Former Holder: Wu Shi-xuan / Deputy General Manager of Operations Performance, TTY Biopharm Group 4. Name, Title, and Resume of the New Holder: Chen Yong-yi / VP of Operations, Sunny Pharmtech Inc. 5. Circumstances of the Change (Resignation, Job Adjustment, Layoff, Retirement, Death, New Appointment, or Dismissal): New Appointment 6. Reason for the Change: New Appointment 7. Effective Date: 115/06/08 8. Other Matters to be Specified: None