Seiho Hospital in Tochigi City, Tochigi Prefecture Begins Accepting Reservations from August for 'Metallo-Balance Test'—Cancer and Cognitive (MCI) Risk Assessment with Just 6mL of Blood

Renatech Inc. (Headquarters: Isehara City, Kanagawa Prefecture), a company that develops health indicators based on trace elements and applies them in real-world settings, announces the opening of reservation bookings for its self-developed and provided screening test, the 'Metallo-Balance Test,' which evaluates the risk of cancer and MCI (Mild Cognitive Impairment). Reservations are now open for testing periods from August to October 2026 at Seiho Hospital (Tochigi City, Tochigi Prefecture), a partner medical institution.

By establishing a continuous testing system at this hospital, access to the 'Metallo-Balance Test' in the Tochigi City area will be stabilized, contributing as a practical option for local residents' daily health management and pre-disease care.

Going forward, Renatech will continue to maintain and expand its testing network in collaboration with partner medical institutions nationwide, aiming to encourage more people to take interest in their health and use the test as a trigger to review their daily health habits and lifestyle for preventive care.

What is the Metallo-Balance (MB) Test?

The Metallo-Balance Test is a risk screening (triage) test that objectively evaluates the risk of cancer and MCI (Mild Cognitive Impairment) at the time of blood draw by analyzing the concentration balance of 17 trace elements (metal elements) in the blood.

### Key Features of the Test

- Only one 6mL blood draw: Blood is safely collected under the proper management of medical institutions. The test takes approximately 15 minutes, minimizing physical burden and ensuring safety.

- Site-specific 'Cancer Risk Test': In a single blood draw, cancer risks are evaluated by site (6 sites for men, 9 sites for women) and scored on a four-tier scale from A to D. - [Men] Lung cancer, stomach cancer, liver cancer, pancreatic cancer, colorectal cancer, prostate cancer - [Women] Lung cancer, stomach cancer, liver cancer, pancreatic cancer, colorectal cancer, breast cancer, cervical cancer, endometrial cancer, ovarian cancer

- Comprehensive 'Cognitive Risk Test (MCI Risk Assessment)': Evaluates all types of cognitive disorders, including Alzheimer's type, vascular type, and Lewy body type.

- Proven research track record and international recognition: Developed through joint research with Kanagawa Cancer Center and Chiba Cancer Center, supported by a research grant from the Ministry of Economy, Trade and Industry's Go-Tech program. Patented in 9 countries including Japan, with over 100,000 test participants cumulatively (from April 2019 to March 2026).

Testing Procedure and Key Pre-Test Instructions

- Application: Apply via website or phone. A complete set of test documents will be delivered to your home approximately one week before your scheduled appointment.

- Test Day (Blood Draw): Due to the fully reserved system, blood collection proceeds smoothly (takes about 15 minutes). Payment is on a post-pay basis, so no on-site payment is required.

- Result Notification: Approximately 3 weeks after blood draw, an invoice (payment slip) will be mailed to your home, followed by the test results approximately 5 weeks after.

### Key Pre-Test Instructions

- Food and alcohol: No food after 9 PM the previous day. No alcohol from the previous day. - Hydration: Drink plenty of water to facilitate blood collection. - Medications and supplements: Over-the-counter drugs and supplements should be avoided from the previous day. Prescription medications should be taken as usual.

Test Fees (Private-Pay Healthcare)

This test is a private-pay service not covered by health insurance. Choose from the following plans based on your needs:

- Cancer Risk Test: ¥19,800 (tax included) - Cognitive Risk Test: ¥19,800 (tax included) - Combined Cancer and Cognitive Risk Test: ¥24,200 (tax included)

- *Displayed prices are standard prices. - *Payment will be made via 'DSK Post-Pay,' delivered to your home after blood draw. - *Some medical institutions may not offer one of the tests.

Eligibility and Important Notes for the Metallo-Balance Test

### Age Eligibility

- Cancer Risk Test: Japanese nationals aged 20 to 80 - Cognitive Risk Test: Japanese nationals aged 50 to 80

- *The test was developed based on data from Japanese individuals within the above age ranges. While individuals outside this age range or non-Japanese nationals may take the test, results will be considered 'reference values' only. Please understand this in advance.

### Individuals Who Cannot Take the Test

- Pregnant individuals or those within 6 months postpartum - Individuals currently undergoing cancer treatment or who completed treatment less than 1 year ago - Individuals undergoing dialysis - Individuals with fractures, blood disorders, or immunodeficiency (excluding lipid disorders such as hypertriglyceridemia) - Individuals in poor health (e.g., sleep deprivation, after an all-nighter, immediately after intense exercise, under severe stress, or experiencing symptoms such as cold, asthma, shingles, allergic rash, or allergic rhinitis)

Overview of Partner Medical Institution

- Testing Hours: Mondays to Saturdays (excluding holidays and clinic closure days) - Medical Institution Name: Seiho Hospital - Address: 273-3 Kanazaki, Nishikata-machi, Tochigi City, Tochigi Prefecture 322-0601 🅿️ Parking available 📍MAP - Access: 5-minute walk from 'Kanazaki Station' on the Tobu Nikko Line - Available Tests: Cancer Risk Test and Cognitive Risk Test

### Check Available Testing Dates and Make a Reservation

Testing schedules for August to October, as well as the latest schedules from November onward, can be checked and booked at any time via the web booking system below.

Metallo-Balance Test Online Reservation: https://metallo-balance.net/entry/

#### Steps to Check Dates and Apply

- From the URL above, select 'General Public' (red button) - Select the corresponding region ('Kanto Region > Tochigi Prefecture') under 'Find a Testing Site' - Select 'Seiho Hospital' as the testing site to view currently available testing dates. - *Each testing slot has a capacity limit. Once full, registration will close. Please understand in advance.

### Important Request Regarding Testing (Please Read Carefully)

- Please refrain from contacting the medical institution directly: The hospital front desk or phone line cannot handle inquiries or applications for this test. All inquiries and applications must be directed to Renatech.

### For More Details and Applications

- Metallo-Balance Test Information Site (for full test details): https://www.mbkensa.com/ - Toll-Free Hotline: 0120-785-602 (Renatech: Weekdays 9:00–17:00)

### Digital Brochure: Metallo-Balance Test

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### Partner Medical Institutions Nationwide Are Also Recruiting! For Information on Introducing the Metallo-Balance Test

Metallo-Rona-chan, the Official Character of Metallo-Balance

Renatech Inc. is an innovation company developing proprietary technologies in the medical and health fields, as well as environmental fields, aiming for early risk assessment of diseases such as cancer. The company has been selected for the '300 Outstanding SMEs and Small-Scale Enterprises' by the Ministry of Economy, Trade and Industry and the Small and Medium Enterprise Agency, recognizing its high technological capability and social contribution.

Among its offerings, the 'Metallo-Balance Test' analyzes the concentration of 17 trace elements in the blood to assess the risk of cancer