【Kawasaki City, Kanagawa Prefecture】'Metallo-Balance Test' for Assessing Cancer and Cognitive (MCI: Mild Cognitive Impairment) Risks with Just 6mL of Blood Sample Now Accepting Reservations at Onoda Clinic Starting August

Renatech Inc. (Headquarters: Isehara City, Kanagawa Prefecture), a company that develops health indicators based on trace elements and applies them to real-world use, announces the opening of reservation bookings for its self-developed and provided screening test, the 'Metallo-Balance Test,' which evaluates risks for cancer and MCI (Mild Cognitive Impairment), at its partner medical institution 'Onoda Clinic' (Miyamae Ward, Kawasaki City, Kanagawa Prefecture) for the period from August to October 2026.

With the establishment of a continuous testing system at this clinic, access to the 'Metallo-Balance Test' in the Kawasaki City, Kanagawa area will be stably secured, contributing as a convenient option for local residents' daily health management and pre-disease care.

The company will continue to maintain and expand testing availability in collaboration with partner medical institutions nationwide, aiming to encourage more people to take interest in their health and use it as an opportunity to review daily health habits and lifestyle for preventive care.

What is the Metallo-Balance (MB) Test?

The Metallo-Balance Test is a risk screening (triage) test that objectively evaluates the risk of cancer and MCI (Mild Cognitive Impairment) at the time of blood draw by analyzing the concentration balance of 17 trace elements (metal elements) in the blood.

### Features of the Test

- Only one 6mL blood draw: Blood is safely collected under proper medical supervision. The test takes approximately 15 minutes, minimizing physical burden and ensuring safety.

- Organ-specific 'Cancer Risk Test': Assesses cancer risk by body part (6 sites for men, 9 for women) in a single blood draw, providing a 4-tier score from A to D. - [Men] Lung cancer, stomach cancer, liver cancer, pancreatic cancer, colorectal cancer, prostate cancer - [Women] Lung cancer, stomach cancer, liver cancer, pancreatic cancer, colorectal cancer, breast cancer, cervical cancer, endometrial cancer, ovarian cancer

- Comprehensive 'Cognitive Risk Test (MCI Risk Assessment)': Evaluates all types of cognitive impairment, including Alzheimer's, vascular, and Lewy body types.

- Proven research results and international recognition: Developed with research funding from the METI Go-Tech program and through joint research with the Kanagawa Cancer Center and Chiba Cancer Center. Patented in 9 countries including Japan, with over 100,000 test-takers cumulatively (from April 2019 to March 2026).

Testing Process and Key Pre-Test Instructions

- ※ Due to the need for document mailing procedures, advance registration is required approximately 3 weeks before the desired test date (by complete reservation system).

- Application: Apply via website or phone. A complete set of test documents will be delivered to your home about one week before the appointment.

- Test Day (Blood Draw): With a fully reserved system, blood collection proceeds smoothly (takes about 15 minutes). Payment is on a post-pay basis, so no on-site payment is required on the day.

- Result Notification: The invoice (payment slip) will be mailed to your home approximately 3 weeks after blood draw, and test results approximately 5 weeks later.

### Key Pre-Test Instructions

- Food and Alcohol: No food after 9 PM the previous day. No alcohol from the previous day. - Hydration: Drink plenty of water to facilitate blood collection. - Medications and Supplements: Discontinue over-the-counter medicines and supplements from the previous day. Continue taking prescribed medications as usual.

Test Fees (Private Pay)

This test is a private-pay service not covered by health insurance. Choose from the following plans based on your needs:

- Cancer Risk Test: 19,800 JPY (tax included) - Cognitive Risk Test: 19,800 JPY (tax included) - Combined Cancer and Cognitive Risk Test: 24,200 JPY (tax included)

- ※ Listed prices are standard rates. - ※ Payment will be via 'DSK Postpay,' delivered to your home after blood draw. - ※ Some medical institutions may not offer one of the tests.

Eligibility and Important Notes for the Metallo-Balance Test

### Age Eligibility

- Cancer Risk Test: Japanese nationals aged 20 to 80 - Cognitive Risk Test: Japanese nationals aged 50 to 80

- ※ This test was developed based on data from Japanese individuals within the above age ranges. While individuals outside these age groups or foreign nationals may take the test, results will be for 'reference only.' Please understand this in advance.

### Individuals Who Cannot Take the Test

- Pregnant individuals or those within 6 months postpartum - Individuals currently undergoing cancer treatment or within 1 year after completion - Individuals undergoing dialysis - Individuals with fractures, blood disorders, or immunodeficiency (excluding lipid abnormalities such as high triglycerides) - Individuals in poor health (e.g., lack of sleep, after all-nighters, immediately after intense exercise, under severe stress, or experiencing symptoms such as cold, asthma, shingles, allergic rashes, or rhinitis)

Overview of Partner Medical Institution

- Test Schedule: Mondays, Wednesdays, and Fridays (excluding holidays and clinic closures) - Medical Institution Name: Onoda Clinic - Address: 6-22-14 Umekawa, Miyamae Ward, Kawasaki City, Kanagawa 216-0035 📍MAP - Access: 8-minute walk from 'Miyazakidai' Station on the Tokyu田园都市 Line - Available Tests: Cancer Risk Test and Cognitive Risk Test

- ▼ Check Available Dates and Book Here Schedules for August to October and the latest updates from November onward can be viewed and booked anytime via the web reservation system below.

Metallo-Balance Test Web Reservation: https://metallo-balance.net/entry/

<Steps to Check Dates and Apply>

- Select 'General Public' (red button) on the URL above - Select the region (Kanto > Kanagawa Prefecture) under 'Find Test Site' - Select 'Onoda Clinic' as the test site to view currently available specific test dates. ※ Each testing slot has a capacity limit. Registration closes once full, so please understand in advance.

- ⚠️ Important Request Regarding Testing (Please Read) Please refrain from contacting the medical institution directly: The hospital front desk or phone line cannot handle inquiries or applications for this test. Please contact Renatech for any questions or applications.

- For Details and Applications

Metallo-Balance Test Information Site (for full details): https://www.mbkensa.com/

Toll-Free Hotline: 0120-785-602 (Renatech: Weekdays 9:00–17:00)

- ▼ Digital Version of Metallo-Balance Test Brochure

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- 🏥 Partner medical institutions nationwide are also being recruited! For information on introducing the Metallo-Balance Test, click here.

Metallo-Balance Original Character: Metalona-chan

Renatech Inc. is an innovative company developing proprietary technologies in the medical and health fields, aiming for early risk assessment of diseases such as cancer, as well as in environmental fields. It has been selected for the '300 Outstanding SMEs and Small Businesses' program by METI and the Small and Medium Enterprise Agency, recognizing its exceptional technological capabilities and social contributions.

Among its innovations, the 'Metallo-Balance Test' analyzes the concentration of 17 trace elements in the blood to assess the risk of cancer and