[Paper Published] Conceptual Framework Reorganizing Obstetric DIC Pathophysiology Published in Thrombosis Research

### Overview

Medical Education Co., Ltd. (Suginami-ku, Tokyo; CEO: Takashi Ochiai) is pleased to announce that a research paper titled "Toward an endothelium-centered framework for obstetric disseminated intravascular coagulation: Harmonizing pathophysiology, diagnosis, and treatment," authored by Dr. Ryo Kamidani and colleagues at Gifu University Graduate School of Medicine, has been published in the academic journal *Thrombosis Research*.

This review paper reorganizes the pathophysiology of obstetric Disseminated Intravascular Coagulation (DIC) from a new perspective focusing on vascular endothelial injury. MEDICAL FIG., operated by Medical Education Co., Ltd., was responsible for producing the conceptual figure (Figure) included in this paper.

### Figure Used in This Research

The conceptual figure reorganizes obstetric DIC pathophysiology from two perspectives: "placental/amniotic fluid-derived hemostatic load" and "vascular endothelial injury." It illustrates how multiple causes converge into a common endothelial pathology, leading to final clinical symptoms.

### Researcher Information

* **Researcher:** Dr. Ryo Kamidani * **Affiliation:** Advanced Critical Care Center, Gifu University Hospital * **Authors:** Ryo Kamidani, Hideshi Okada

### Role of the Figure in This Research

In this study, various diseases causing obstetric DIC are organized by etiology. It presents a pathological framework where each cause leads to hypercoagulation, hyperfibrinolysis, and microcirculatory disturbances through vascular endothelial injury (endothelial glycocalyx damage). The produced Figure was designed as a bird's-eye view conceptual diagram to reorganize obstetric DIC pathophysiology—which cannot be fully explained by the traditional "bleeding type/thrombotic type" dichotomy—around the core factors of hemostatic load and endothelial damage.

### Key Considerations in Figure Production

The Figure was created as an introductory conceptual diagram for the review paper. Information is organized in a three-stage structure: etiology, pathogenesis, and clinical symptoms, reconstructed as a flowchart where multiple causes converge into common endothelial pathology. Special care was taken in the illustration of the endothelial glycocalyx to ensure expressions that minimize interpretational differences among experts.

### Paper Information

* **Title:** Toward an endothelium-centered framework for obstetric disseminated intravascular coagulation: Harmonizing pathophysiology, diagnosis, and treatment * **Journal:** Thrombosis Research * **Publication Date:** April 30, 2026 * **DOI:** 10.1016/j.thromres.2026.109694

### About Medical Education Co., Ltd. / MEDICAL FIG.

Medical Education Co., Ltd. supports the organization of thoughts and visualization of research structures for researchers and experts, primarily in the fields of medicine, life sciences, and healthcare. MEDICAL FIG. is a visualization support service that assists in the communication of research results through the production of paper figures, graphical abstracts, and schematic diagrams.