Additional Investment Made in Dioseve Inc., Aiming for Social Implementation of Reproductive Regenerative Medicine Using iPS Cells

MiraiDova Inc. (Headquarters: Minato-ku, Tokyo; Chairman and President: Daisuke Sawada, hereinafter "MiraiDova") is pleased to announce that the Asuka Innovation Investment Limited Partnership (hereinafter "Asuka Innovation Fund"), jointly established with Asuka Pharmaceutical Co., Ltd. (Headquarters: Minato-ku, Tokyo; President: Sota Yamaguchi, hereinafter "Asuka Pharmaceutical"), has made an additional investment in Dioseve Inc. (Headquarters: Koto-ku, Tokyo; Representative Director: Kazuma Kishida, hereinafter "Dioseve"), a company working on the development of reproductive regenerative medicine using iPS cell-derived eggs.

◆About the Investee Company

Dioseve is a startup with the mission "To provide new options for all lives," aiming for the social implementation of reproductive regenerative medicine using iPS cells. Current infertility treatments face serious challenges, including high physical and economic burdens on patients, and still low success rates. The company has developed a proprietary technology to produce ovarian cells (granulosa cells) that promote the maturation of eggs from iPS cells, centered around its culture product (DIOS-101). This product is expected to improve the success rate of in vitro fertilization by maturing immature eggs, which were previously difficult to use in treatment.

Concurrently, the company is advancing the development of this technology as a means to significantly reduce hormone administration and the number of hospital visits, thereby greatly alleviating the burden on patients. Dioseve aims for early commercialization in Japan and the United States as a new standard for infertility treatment.

Company Name Dioseve Inc.

Representative Director Kazuma Kishida

Headquarters Location Mitsui Link Lab Kiba 2, Room 223, 1-17-8 Shinkiba, Koto-ku, Tokyo

Date of Establishment June 2021

URL https://dioseve.com/

◆About the Asuka Innovation Fund

(1) Investment Objective

The fund aims to secure "strategic returns" through investments in startup companies where business synergies with Asuka Pharmaceutical and its group companies are expected.

(2) Investment Themes

① Startups aiming to solve issues related to menstruation, infertility, and menopausal disorders. ② Startups researching novel modalities and drug delivery in pharmaceutical research. ③ Startups developing new digital health solutions and applications. ④ Startups involved in animal health and diagnostic business.

◆About MiraiDova

MiraiDova is involved in "Regional Revitalization Funds" to support venture companies in local areas, "CVC Funds" to promote open innovation for business companies, and "Theme-based Funds" that support industry revitalization by focusing on specific investment areas. In addition to financial investment, MiraiDova also provides support for business development, human resource development, and business consulting to ensure long-term business continuity.

Company Name MiraiDova Inc.

Subsidiary of AI Fusion Capital Group Co., Ltd.

(TSE Standard, Securities Code 254A) 100% subsidiary

Chairman and President Daisuke Sawada

Headquarters Location 1-9-9 Roppongi, Minato-ku, Tokyo

URL https://www.fvc.co.jp/