Setsunan University: Pupil Response During Dark Adaptation Changes with Time of Day and Aging

A research group led by Lecturer Yoshinori Iba at Setsunan University's Faculty of Science and Engineering has revealed that pupil response during dark adaptation in mice is influenced by circadian rhythms and aging. While traditional research focused on pupil size, this study analyzed how it changes over time. The results showed that responses differ between day and night and that aging alters the response pattern. Specifically, pupil contraction after dark adaptation involves both fast and slow responses, both of which are significantly affected by aging. This finding highlights the importance of analyzing temporal changes in pupil function assessment, offering new perspectives for aging and circadian rhythm research. The study was published in the 'Journal of Biological Rhythms'.